Efficacy and safety of anti-obesity drugs in metabolic dysfunction-associated steatotic liver disease: An updated review

Figure 2 Fibrosis-4 score: Components and interpretation flowchart. Flowchart illustrating the calculation and interpretation of the fibrosis-4 score, a non-invasive marker for advanced fibrosis in metabolic dysfunction-associated steatotic liver disease. The formula incorporates age, aspartate aminotransferase, alanine aminotransferase, and platelet count. Cut-off values are stratified to classify risk: < 1.3 indicates low risk, 1.3-2.67 is indeterminate, and > 2.67 suggests high risk, warranting further evaluation with vibration-controlled transient elastography or enhanced liver fibrosis testing. FIB-4: Fibrosis-4; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; VCTE: Vibration-controlled transient elastography; ELF: Enhanced liver fibrosis.