Added value of the albumin-bilirubin score in predicting liver-related complications and mortality in metabolic-associated steatotic liver disease

Table 2 Prognostic performance of albumin-bilirubin and other non-invasive scores on 8-year liver-related complications and all-cause mortality

Scores (n = 1163)	8-year liver-related complications	8-year all-cause mortality
Based-prognostic score
AUROC (95%CI)	0.67 (0.62-0.73)	0.78 (0.72-0.83)
Euclidian cut-off values	≥ -2.39	≥ -2.60
Sensitivity/specificity (%)	62.89/64.75	72.09/72.98
PPV/NPV (%)	14.25/94.93	12.85/96.48
Positive/negative LR	1.78/0.57	2.67/0.38
Correctly classified (%)	64.59	72.91
Based-prognostic score plus ALBI
AUROC (95%CI)	0.74 (0.68-0.79)	0.83 (0.79-0.88)
Euclidian cut-off values	≥ -2.44	≥ -2.70
Sensitivity/specificity (%)	65.98/67.72	74.42/75.95
PPV/NPV (%)	16.00/95.53	14.50/97.02
Positive/negative LR	2.04/0.50	3.09/0.34
Correctly classified (%)	67.57	75.84
ALBI
AUROC (95%CI)	0.72 (0.66-0.77)	0.81 (0.76-0.86)
Euclidian cut-off values	≥ -2.82	≥ -2.77
Sensitivity/specificity (%)	66.00/66.60	72.09/72.52
PPV/NPV (%)	15.68/95.42	17.32/97.02
Positive/negative LR	1.98/0.51	2.62/0.38
Correctly classified (%)	66.55	72.48
FIB-4
AUROC (95%CI)	0.64 (0.58-0.70)	0.72 (0.65-0.78)
Euclidian cut-off values	≥ 1.51	≥ 1.76
Sensitivity/specificity (%)	62.00/62.84	68.60/71.68
PPV/NPV (%)	13.57/94.62	16.21/96.62
Positive/negative LR	1.67/0.60	2.42/0.44
Correctly classified (%)	62.77	71.45
Comparison of AUROC1
Based-prognostic scores vs based-prognostic scores plus ALBI	0.003a	0.002a
Based-prognostic scores plus ALBI vs ALBI	0.193	0.152
ALBI vs FIB-4	0.033a	0.004a

^aP < 0.05.

¹P value by DeLong test.

AUROC: Area under the receiver operating characteristic curve; ALBI: Albumin-bilirubin; LR: Likelihood ratio; NPV: Negative predictive value; PPV: Positive predictive value; FIB-4: Fibrosis-4; CI: Confidence interval.