Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells

doi:10.3748/wjg.v31.i36.111557

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2025; 31(36): 111557
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.111557

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Figure 8 Schematic diagram illustrates peroxiredoxin 1 as a critical damage-associated molecular pattern to inhibit the malignant biological behavior of colon cancer cells. Extracellular peroxiredoxin 1 induces pyroptosis of colon cancer cells by activating the NLRP3 inflammasome/Caspase-1/GSDMD pathway, which can inhibit the viability, proliferation, migration and invasion of cancer cells. Prdx1: Peroxiredoxin 1.

Citation: He Y, Liu J, Zhou N, Xie LX, Jiang YF, Chen CL. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells. World J Gastroenterol 2025; 31(36): 111557
URL: https://www.wjgnet.com/1007-9327/full/v31/i36/111557.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i36.111557

He Y, Liu J, Zhou N, Xie LX, Jiang YF, Chen CL. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells. World J Gastroenterol 2025; 31(36): 111557 [PMID: 41025079 DOI: 10.3748/wjg.v31.i36.111557]

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