Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells

Figure 1 Peroxiredoxin 1 is up-regulated in colorectal cancer tissues. A: The mRNA expression of peroxiredoxin 1 (Prdx1) was detected by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues from patients with colorectal cancer (CRC), n = 60/group; B: The protein expression of Prdx1 was detected by western blotting in tumor tissues and adjacent normal tissues from patients with CRC, n = 20/group; C: Immunohistochemistry staining for Prdx1 in tumor tissues and adjacent normal tissues from patients with CRC, each representative image is from one sample (n = 20/group), scale bar: 100 μm (200 ×). Data are expressed as the mean ± SD; ^cP < 0.001. Prdx1: Peroxiredoxin 1; CRC: Colorectal cancer.