Colonic neoplasia and celiac disease: A systematic review

Table 2 Studies showing the association between celiac disease and colorectal adenoma

Ref.	Year	Country	Design	Celiac disease cases	Colon adenoma cases	Survival and mortality findings
Pereyra et al[22]	20131	Argentina	Multicenter, retrospective case–control study	118	Polyps: 24; adenoma: 18; advanced colonic lesions: 3	On multivariate analysis, there was increased risk of colonic adenoma observed in CD patient aged ≥ 75 years old. Polyps, OR = 6.59 (CI: 1.64-26.57), P = 0.008; adenoma, OR = 8.12 (CI: 1.83-35.94), P = 0.005; advanced colonic lesions, OR = 15.14 (CI: 1.23-186.67), P = 0.03
Lasa et al[107]	20181	Argentina	Hospital-based retrospective case control study	57	Adenoma: 27; left sided adenoma: 21; right sided adenoma: 10; advanced adenoma: 6	Adenoma, OR = 2.31 (CI: 1.18-4.53), P = 0.01; left sided adenoma, OR = 2.69 (CI: 1.29-5.61), P = 0.006; right sided adenoma, OR = 1.18 (CI: 0.5-2.76), P = 0.7; advanced adenoma, OR = 1.27 (CI: 0.43-3.71), P = 0.6
Lasa et al[109]	20182	Argentina	Systemic review and meta-analysis	367		No increased prevalence of colorectal adenomas in CD patients, compared with controls [OR = 0.94 (CI: 0.65-1.38), P = 0.76], and no significant difference was observed when assessing the prevalence of advanced adenomas [OR = 0.97 (CI: 0.48-1.97)], no significant heterogeneity was observed (I2 = 26%)
González et al[110]	20122	Argentina	Hospital-based retrospective case control study	178	Polyps: 9; adenoma: 7; advanced colonic lesions: 2	No significant association between CD and colorectal adenoma among CD patients and control; polyps: OR = 1.48 (CI: 0.59-3.73), adenoma: OR = 1.89 (CI: 0.66-5.42), advanced colonic lesions: OR = 1.34 (CI: 0.26-7.05)
Lebwohl et al[108]	20101	United States	Hospital-based retrospective case control study	180	23	On multivariate analysis, age (OR per year 1.04, 95%CI: 1.02-1.07) and male gender (OR = 2.33, 95%CI: 1.36-3.98) are associated with adenomas; no significant association between CD and adenoma detection (OR = 0.75, 95%CI: 0.41-1.34), P = 0.33

¹Studies showed increased risk.

²Studies showed decreased risk.

CD: Celiac disease; OR: Odds ratio; CI: Confidence interval.