Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1

doi:10.3748/wjg.v31.i35.108139

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2025; 31(35): 108139
Published online Sep 21, 2025. doi: 10.3748/wjg.v31.i35.108139

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Figure 7 Ambroxol increased thioredoxin reductase 1 in the liver of cyclophosphamide-administered rats. A and B: Ambroxol (ABX) upregulated the expression of thioredoxin reductase 1 (TXNRD1) in the liver of rats that received cyclophosphamide (CP). Data are expressed as mean ± SD (n = 6). ^aP < 0.05 and ^cP < 0.001 vs control group, ^fP < 0.001 vs CP; C: Molecular docking showing the interaction between ABX and TXNRD1. ABX: Ambroxol; CP: Cyclophosphamide; TXNRD1: Thioredoxin reductase 1.

Citation: Alruhaimi RS, Hassanein EHM, Alnasser SM, Ahmeda AF, Althagafy HS, Abd El-Ghafar OAM, Mahmoud AM. Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1. World J Gastroenterol 2025; 31(35): 108139
URL: https://www.wjgnet.com/1007-9327/full/v31/i35/108139.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i35.108139

Alruhaimi RS, Hassanein EHM, Alnasser SM, Ahmeda AF, Althagafy HS, Abd El-Ghafar OAM, Mahmoud AM. Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1. World J Gastroenterol 2025; 31(35): 108139 [PMID: 41024762 DOI: 10.3748/wjg.v31.i35.108139]

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