Multiparametric magnetic resonance imaging of deep learning-based super-resolution reconstruction for predicting histopathologic grade in hepatocellular carcinoma

Table 4 Univariable and multivariable cox proportional hazards analyses for overall survival and recurrence-free survival

Variable	Overall survival				Recurrence-free survival
	Univariable analysis		Multivariable analysis		Univariable analysis		Multivariable analysis
Signature from SR MRI	1.67 (1.21, 2.30)	0.002	1.81 (1.29, 2.55)	0.001	1.39 (1.04, 1.88)	0.028	1.36 (1.02, 1.85)	0.042
Age (> 65 years)	1.20 (0.80, 1.79)	0.381			1.12 (0.79, 1.59)	0.533
Gender (male)	1.08 (0.70, 1.67)	0.723			1.13 (0.75, 1.71)	0.559
HBV	0.97 (0.67, 1.39)	0.855			0.93 (0.67, 1.29)	0.677
Cirrhosis	1.30 (0.94, 1.80)	0.118			1.15 (0.86, 1.54)	0.341
MVI	1.78 (1.28, 2.47)	< 0.001	1.48 (1.04, 2.09)	0.029	1.80 (1.34, 2.42)	0.001	1.67 (1.23, 2.28)	0.001
INR (> 1.5 ratio)	2.31 (0.32, 16.64)	0.405			2.61 (0.64, 10.54)	0.179
AFP	1.48 (1.02, 2.14)	0.04	1.53 (1.06, 2.19)	0.219	1.44 (1.03, 2.02)	0.031
Multiple	1.07 (0.67, 1.72)	0.766			1.59 (1.07, 2.37)	0.021	1.53 (1.03, 2.28)	0.036
Pseudocapsule	0.74 (0.52, 1.04)	0.083			0.88 (0.65, 1.20)	0.426
Tumor size	1.38 (1.01, 1.90)	0.049	1.53 (1.06, 2.19)	0.022	1.38 (1.01, 1.91)	0.048	1.38 (0.96, 1.98)	0.08

Hazard ratio, 95%CI and P value were reported to measure the effects; SR: Super-resolution; MRI: Magnetic resonance imaging; HBV: Hepatitis B virus; MVI: Microvascular invasion; INR: International normalized ratio; AFP: Α-fetoprotein.