B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway

Figure 5 B-cell CLL/Lymphoma 10 regulates DLAT through NF-κB p65 phosphorylation. A: Co-IP of DLAT and B-cell CLL/Lymphoma 10 (BCL10); B: AlphaFold3 predicted binding model (ipTM < 0.6); C: Western blot of p65 and p-p65 (Ser536). ^cP < 0.001; D: Immunofluorescence of p65 (red) and DAPI (blue); orange arrows indicate nuclear translocation; E: Western blot after p65 transfection in BCL10-knockdown cells. ^cP < 0.001; F: Western blot after BAY 11-7082 treatment. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001; G: Western blot after DLAT knockout. ^cP < 0.001.