B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway

doi:10.3748/wjg.v31.i34.109825

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2025; 31(34): 109825
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.109825

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Figure 4 B-cell CLL/Lymphoma 10 affects cuproptosis sensitivity through DLAT regulation. A: Quantitative PCR analysis of cuproptosis-related genes; B: Western blot of B-cell CLL/Lymphoma 10 (BCL10) and DLAT expression. ^aP < 0.05; ^bP < 0.01; C: TEM images of mitochondrial morphology (orange arrows: Damaged mitochondria with cristae disruption); D: Immunofluorescence of indicated proteins after elesclomol-Cu treatment; E: Non-reducing Western blot of DLAT oligomers; F and G: Flow cytometry after DLAT knockdown. ^cP < 0.001.

Citation: Xiao PT, Li CF, Liu YD, Zhong J, Cui XL, Liu C, Yang W. B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway. World J Gastroenterol 2025; 31(34): 109825
URL: https://www.wjgnet.com/1007-9327/full/v31/i34/109825.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i34.109825

Xiao PT, Li CF, Liu YD, Zhong J, Cui XL, Liu C, Yang W. B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway. World J Gastroenterol 2025; 31(34): 109825 [PMID: 40937457 DOI: 10.3748/wjg.v31.i34.109825]

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