B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway

Figure 1 B-cell CLL/Lymphoma 10 promotes the proliferation of colorectal cancer cells in vitro and in vivo. A and B: Colony formation assays showing proliferation ability in SW480 and SW620 cell lines with BCL10 knockdown (SH-BCL10) or overexpression (OE-BCL10). NC1: Scrambled shRNA control; NC2: Empty vector control. ^cP < 0.001; C: Western blot analysis of MYC and Ki67 expression. ^bP < 0.01; ^cP < 0.001; D: Immunohistochemical staining of MYC and Ki67 in xenograft tumors. Scale bars: 50 μm (main panels, 20 × magnification); 20 μm (insets, 40 × magnification); E: EdU assay for cell proliferation detection. Scale bars: 50 μm.