Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study

doi:10.3748/wjg.v31.i34.109718

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Gastroenterol. Sep 14, 2025; 31(34): 109718
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.109718

Table 5 Diagnostic accuracy of homocysteine

	Hcy cut-off value	Sensitivity	Specificity	PPV	NPV	Observed agreement	AUROC
Adenocarcinoma
Overall	≥ 15.1	191/240; 79.58 (73.92-84.5)	33/61; 54.1 (40.85-66.94)	191/219; 87.21 (82.05-91.33)	33/82; 40.24 (29.56-51.66)	224/301; 74.42 (69.1-79.25)	0.706 (0.631-0.781)
< 65 years	≥ 15.1	122/156; 78.21 (70.9-84.41)	8/21; 38.1 (18.11-61.56)	122/135; 90.37 (84.1-94.77)	8/42; 19.05 (8.6-34.12)	130/177; 73.45 (66.3-79.79)	0.621 (0.496-0.747)
≥ 65 years	≥ 15.18	69/84; 82.14 (72.26-89.65)	25/40; 62.5 (45.8-77.27)	69/84; 82.14 (72.26-89.65)	25/40; 62.5 (45.8-77.27)	94/124; 75.81 (67.3-83.04)	0.755 (0.660-0.850)
Females	≥ 12.5	75/109; 68.81 (59.22-77.34)	18/23; 78.26 (56.3-92.54)	75/80; 93.75 (86.01-97.94)	18/52; 34.62 (21.97-49.09)	93/132; 70.45 (61.89-78.07)	0.780 (0.683-0.877)
Males	≥ 15.1	94/131; 71.76 (63.23-79.27)	23/38; 60.53 (43.39-75.96)	94/109; 86.24 (78.32-92.09)	23/60; 38.33 (26.07-51.79)	117/169; 69.23 (61.68-76.09)	0.653 (0.546-0.761)
Adenocarcinoma or high-risk polyps
Overall	≥ 12.26	84/133; 63.16 (54.36-71.35)	107/168; 63.69 (55.93-70.96)	84/145; 57.93 (49.46-66.07)	107/156; 68.59 (60.68-75.78)	191/301; 63.46 (57.74-68.91)	0.670 (0.609-0.730)
< 65 years	≥ 15.1	80/91; 87.91 (79.4-93.81)	31/86; 36.05 (25.97-47.12)	80/135; 59.26 (50.47-67.63)	31/42; 73.81 (57.96-86.14)	111/177; 62.71 (55.14-69.85)	0.632 (0.551-0.714)
≥ 65 years	≥ 12.16	28/42; 66.67 (50.45-80.43)	57/82; 69.51 (58.36-79.2)	28/53; 52.83 (38.64-66.7)	57/71; 80.28 (69.14-88.78)	85/124; 68.55 (59.6-76.59)	0.706 (0.610-0.802)
Females	≥ 12.46	55/77; 71.43 (60-81.15)	31/55; 56.36 (42.32-69.7)	55/79; 69.62 (58.25-79.47)	31/53; 58.49 (44.13-71.86)	86/132; 65.15 (56.37-73.23)	0.654 (0.559-0.748)
Males	≥ 14.48	44/56; 78.57 (65.56-88.41)	58/113; 51.33 (41.74-60.84)	44/99; 44.44 (34.45-54.78)	58/70; 82.86 (71.97-90.82)	102/169; 60.36 (52.56-67.78)	0.642 (0.557-0.727)

Hcy: Homocysteine; PPV: Positive predictive value; NPV: Negative predictive value; AUROC: Area under the receiver operating characteristic curve.

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Citation: Cano FX, Duque JM, Seoane L, Puga-Tejada M, Espinoza de los Monteros A, Bermeo P, Junquera E, Pérez D, Martin-Delgado J, Santelli M, Pérez C, Pérez Rivera FJ. Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study. World J Gastroenterol 2025; 31(34): 109718
URL: https://www.wjgnet.com/1007-9327/full/v31/i34/109718.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i34.109718

Cano FX, Duque JM, Seoane L, Puga-Tejada M, Espinoza de los Monteros A, Bermeo P, Junquera E, Pérez D, Martin-Delgado J, Santelli M, Pérez C, Pérez Rivera FJ. Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study. World J Gastroenterol 2025; 31(34): 109718 [PMID: 40937453 DOI: 10.3748/wjg.v31.i34.109718]

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