Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Gastroenterol. Sep 14, 2025; 31(34): 109718
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.109718

Table 3 Description of colorectal lesions found during colonoscopy, n (%)

	Total (n = 873)	No polyps (n = 84)	Low-risk polyps (n = 542)	High-risk polyps (n = 185)	Adenocarcinoma (n = 62)
Location
Left colon	552 (69.3)	5 (62.5)	353 (65.1)	146 (78.9)	48 (77.4)
Right colon	245 (30.7)	3 (37.5)	189 (34.9)	39 (21.1)	14 (22.6)
Size (mm)
< 10	570 (71.5)	6 (75.0)	542 (100.0)	21 (11.4)	1 (1.6)
≥ 10	227 (28.5)	2 (25.0)	-	164 (88.6)	61 (98.4)
Paris classification
Is	554 (69.5)	7 (87.5)	479 (88.4)	65 (35.1)	3 (4.8)
Ip	82 (10.3)	1 (12.5)	20 (3.7)	59 (31.9)	2 (3.2)
Isp	48 (6.0)	-	20 (3.7)	26 (14.1)	2 (3.2)
IIa	36 (4.5)	-	16 (3.0)	20 (10.8)	-
IIb	17 (2.1)	-	7 (1.3)	10 (5.4)	-
IIc	8 (1.0)	-	-	2 (1.1)	6 (9.7)
IIa + IIc	7 (0.9)	-	-	3 (1.6)	4 (6.5)
IIc + IIa	5 (0.6)	-	-	-	5 (8.1)
Lateral spread tumor	40 (5.0)	-	-	-	40 (64.5)
Histology
Adenocarcinoma	62 (7.8)	-	-	-	62 (100.0)
Tubulovillous adenoma	77 (9.7)	-	-	77 (41.6)	-
Tubular adenoma	502 (63.0)	-	406 (74.9)	96 (51.9)	-
Serrated adenoma	3 (0.4)	-	2 (0.4)	1 (0.5)	-
Hyperplastic	90 (11.3)	-	86 (15.9)	4 (2.2)	-
Non-retrieved specimen	44 (5.5)	-	41 (7.6)	3 (1.6)	-
Non-resected specimen	11 (1.4)	-	7 (1.3)	4 (2.2)	-
Inflammatory polyp	5 (0.6)	5 (62.5)	-	-	-
Lipoma	1 (0.1)	1 (12.5)	-	-	-
Normal colonic tissue	2 (0.3)	2 (25.0)	-	-	-
Colonoscopy without findings	76 (8.7)	76 (90.5)	-	-	-

LST: Lateral spread tumor.

Citation: Cano FX, Duque JM, Seoane L, Puga-Tejada M, Espinoza de los Monteros A, Bermeo P, Junquera E, Pérez D, Martin-Delgado J, Santelli M, Pérez C, Pérez Rivera FJ. Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study. World J Gastroenterol 2025; 31(34): 109718
URL: https://www.wjgnet.com/1007-9327/full/v31/i34/109718.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i34.109718

Cano FX, Duque JM, Seoane L, Puga-Tejada M, Espinoza de los Monteros A, Bermeo P, Junquera E, Pérez D, Martin-Delgado J, Santelli M, Pérez C, Pérez Rivera FJ. Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study. World J Gastroenterol 2025; 31(34): 109718 [PMID: 40937453 DOI: 10.3748/wjg.v31.i34.109718]

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