Risk factors and long-term prognosis for colorectal strictures in ulcerative colitis

Table 3 Clinical features of benign and malignant strictures, n (%)

	All stricture cases	Malignant stricture	Benign stricture	P value
Number of patients	116	10	106
Number of strictures				0.409
1	99 (85.3)	9 (90.0)	90 (84.9)
2	16 (13.8)	1 (10.0)	15 (14.2)
3	1 (0.9)	0 (0.0)	1 (0.9)
Male	58 (50.0)	4 (40.0)	54 (50.9)	0.822
Age at diagnosis, year (median, IQR)	38.97 (30.52-49.39)	36.06 (32.19-42.39)	40.69 (29.36-51.95)	0.426
Median age at diagnosis of stricture, year (median, IQR)	47.83 (36.65-60.16)	60.99 (50.58-63.38)	46.80 (36.01-58.10)	0.042
Median duration from diagnosis to stricture formation, year (median, IQR)	5.25 (2.45-12.76)	18.88 (16.29-24.75)	4.49 (2.27-9.64)	< 0.001
Location of the stricture				0.041
Rectum	31 (23.1)	4 (36.4)	27 (22.0)
Left colon	83 (61.9)	3 (27.3)	80 (65.0)
Right colon	20 (14.9)	4 (36.4)	16 (13.0)
Clinical activity until surgery or the end of follow-up				0.016
Clinical remission	31 (26.7)	3 (30.0)	28 (26.4)
Mild activity	28 (24.1)	6 (60.0)	22 (20.8)
Moderate activity	34 (29.3)	1 (10.0)	33 (31.1)
Severe activity	23 (19.8)	0 (0.0)	23 (21.7)
Steroid dependence	28 (24.1)	0 (0.0)	28 (26.4)	0.139
Steroid resistance	8 (6.9)	0 (0.0)	8 (7.5)	1.000
UC-related surgery	64 (55.2)	10 (100.0)	54 (50.9)	0.008
Severe intestinal complications	37 (31.9)	4 (40.0)	33 (31.1)	0.826
Bleeding	8 (6.9)	0 (0.0)	8 (7.5)	1.000
Perforation	5 (4.3)	1 (10.0)	4 (3.8)	0.368
Obstruction	21 (18.1)	2 (20.0)	19 (17.9)	1.000
Fistula	3 (2.6)	1 (10.0)	2 (0.5)	0.239
Toxic megacolon	4 (3.4)	0 (0.0)	4 (3.8)	1.000
All-cause mortality	4 (3.4)	2 (20.0)	2 (1.9)	0.037

IQR: Interquartile range; UC: Ulcerative colitis.