Risk factors and long-term prognosis for colorectal strictures in ulcerative colitis

Table 2 Prognostic outcomes of the stricture and non-stricture group, n (%)

	Stricture group			Non-stricture group (n = 822)	1P value	2P value
	All stricture cases (n = 116)	Malignant stricture group (n = 10)	Benign stricture group (n = 106)
Clinical activity until surgery or the end of follow-up					< 0.001	< 0.001
Clinical remission	31 (26.7)	3 (30.0)	28 (26.4)	372 (45.3)
Mild activity	28 (24.1)	6 (60.0)	22 (20.8)	220 (26.8)
Moderate activity	34 (29.3)	1 (10.0)	33 (31.1)	131 (15.9)
Severe activity	23 (19.8)	0 (0.0)	23 (21.7)	99 (12.0)
Steroid dependence	28 (24.1)	0 (0.0)	28 (26.4)	128 (15.6)	0.020	0.005
Steroid resistance	8 (6.9)	0 (0.0)	8 (7.5)	25 (3.0)	0.066	0.038
UC-related surgery	64 (55.2)	10 (100.0)	54 (50.9)	107 (13.0)	< 0.001	< 0.001
CRC	10 (8.7)			23 (2.8)	0.003
Severe intestinal complications	37 (31.9)	4 (40.0)	33 (31.1)	53 (6.4)	< 0.001	< 0.001
Bleeding	8 (6.9)	0 (0.0)	8 (7.5)	33 (4.0)	0.155	0.157
Perforation	5 (4.3)	1 (10.0)	4 (3.8)	9 (1.1)	0.024	0.077
Obstruction	21 (18.1)	2 (20.0)	19 (17.9)	6 (0.7)	< 0.001	< 0.001
Fistula	3 (2.6)	1 (10.0)	2 (0.5)	3 (0.4)	0.028	0.103
Toxic megacolon	4 (3.4)	0 (0.0)	4 (3.8)	4 (0.5)	0.010	0.004
All-cause mortality	4 (3.4)	2 (20.0)	2 (1.9)	20 (2.4)	0.738	0.993

¹Statistical comparisons were conducted between stricture and non-stricture groups.

²Statistical comparisons were limited to the benign-stricture and non-stricture groups; the malignant-stricture group (n = 10) was summarized descriptively and omitted from the main analyses owing to its small size.

UC: Ulcerative colitis; CRC: Colorectal cancer.