Noninvasive model based on liver and spleen stiffness for predicting clinical decompensation in patients with cirrhosis

doi:10.3748/wjg.v31.i33.107408

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2025; 31(33): 107408
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.107408

Table 3 Univariate analysis of parameters in patients with compensated and decompensated cirrhosis

Parameter	Patients with compensatory stage of cirrhosis, n = 72	Patients with decompensation of cirrhosis, n = 68	t/Z	P value
SSM, kPa	23.50 ± 6.1	18.32 ± 4.2	5.866	< 0.001
PLT, × 10⁹/L	110.51 ± 69.1	61.81 ± 25.7	5.463	< 0.001
LSM, kPa	15.53 ± 5.7	23.86 ± 5.2	-9.023	< 0.001
ALT, IU/L	36.00 (24.00, 47.75)	27.50 (17.00, 42.25)	-2.490	0.013
AST, IU/L	40.50 (26.75, 58.75)	38.00 (29.00, 56.75)	-0.452	0.651
ALP, IU/L	105.00 (77.50, 143.00)	98.50 (79.25, 135.50)	-0.709	0.478
GGT, IU/L	61.00 (28.00, 120.00)	34.50 (19.25, 59.50)	-3.718	< 0.001
SLD, mm	12.99 ± 3.0	15.68 ± 3.1	-5.282	< 0.001
TBIL, μmol/L	29.64 ± 27.0	31.27 ± 16.2	-0.430	0.668
ALB, g/dL	38.69 ± 6.4	34.43 ± 7.4	3.691	< 0.001
TCHO, mmol/L	3.67 ± 1.3	3.09 ± 0.9	2.939	0.004
PT, seconds	12.08 ± 1.9	13.70 ± 2.5	-4.322	< 0.001
INR	1.10 ± 0.2	1.24 ± 0.2	-4.029	< 0.001
PTA,%	84.91 ± 18.9	72.37 ± 17.0	4.123	< 0.001
PVD, mm	12.03 ± 1.6	13.78 ± 2.4	-5.072	< 0.001
CTLV, cm³	1055.93 ± 344.8	898.64 ± 257.3	3.045	0.003
CTSV, cm³	519.10 ± 296.0	842.19 ± 416.3	-5.315	< 0.001

SSM: Spleen stiffness measurement; PLT: Platelet; LSM: Liver stiffness measurement; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; SLD: Spleen length diameter; TBIL: Total bilirubin; ALB: Albumin; TCHO: Total cholesterol; PT: Prothrombin time; INR: International normalized ratio; PTA: Prothrombin activity; PVD: Portal vein diameter; CTLV: Actual liver volume measured by computed tomography; CTSV: Actual spleen volume measured by computed tomography.

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Citation: Yang LB, Gao X, Xu M, Li Y, Dong L, Huang XD, She X, Zhang DY, Zhang QW, Liu CY, Fan ST, Wang Y. Noninvasive model based on liver and spleen stiffness for predicting clinical decompensation in patients with cirrhosis. World J Gastroenterol 2025; 31(33): 107408
URL: https://www.wjgnet.com/1007-9327/full/v31/i33/107408.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i33.107408

Yang LB, Gao X, Xu M, Li Y, Dong L, Huang XD, She X, Zhang DY, Zhang QW, Liu CY, Fan ST, Wang Y. Noninvasive model based on liver and spleen stiffness for predicting clinical decompensation in patients with cirrhosis. World J Gastroenterol 2025; 31(33): 107408 [PMID: 40933462 DOI: 10.3748/wjg.v31.i33.107408]

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