Role of preoperative circulating tumor DNA in predicting occult metastases in resectable and borderline resectable pancreatic ductal adenocarcinoma

Figure 2 Association between circulating tumor DNA status and prognosis. A: Kaplan-Meier curve of postoperative recurrence-free survival (RFS) in circulating tumor DNA (ctDNA)-positive and -negative groups of 125 patients who underwent pancreatectomy, excluding 10 patients who underwent laparotomy. During the observation period of 37.1 months, the median RFS in the ctDNA-positive group was 10.2 months, significantly worse than the 258 months in the ctDNA-negative group (P = 0.023); B: Kaplan-Meier curve of postoperative overall survival in ctDNA-positive and -negative groups of 135 patients. The median overall survival in the ctDNA-positive group was 22.9 months, significantly worse than the 411 months in the ctDNA-negative group (P = 0.039). ctDNA: Circulating tumor DNA.