Role of preoperative circulating tumor DNA in predicting occult metastases in resectable and borderline resectable pancreatic ductal adenocarcinoma

doi:10.3748/wjg.v31.i32.109383

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Gastroenterol. Aug 28, 2025; 31(32): 109383
Published online Aug 28, 2025. doi: 10.3748/wjg.v31.i32.109383

Table 1 Baseline characteristics of patients

Variables	n = 135
Age, years, median (IQR)	71 (65-76)
Sex, male/female	70/65
Baseline CA19-9, U/mL, median (IQR)	76.6 (21.3-258.2)
Preoperative CA19-9, U/mL, median (IQR)	30.9 (11.6-100.2)
¹Resectability status, resectable/BR	91/44
Tumor location, Ph/Pb/Pt	98/29/8
Neoadjuvant therapy, present	109
Chemotherapy, present	99
Chemoradiotherapy, present	10
Baseline tumor size, mm, median (IQR)	22.5 (17-30)
Preoperative tumor size, mm, median (IQR)	18 (13.8-25)

¹According to the National Comprehensive Cancer Network criteria.

BR: Borderline resectable; IQR: Interquartile range; Pb: Pancreatic body; Ph: Pancreatic head; Pt: Pancreatic tail; CA19-9: Carbohydrate antigen 19-9.

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Citation: Murakami T, Imamura M, Kimura Y, Watanabe K, Shinohara Y, Nakamura T, Low SK, Motoya M, Kawakami Y, Masaki Y, Kubo T, Yoshida M, Yoshida E, Kato T, Kukita K, Kyuno D, Takemasa I. Role of preoperative circulating tumor DNA in predicting occult metastases in resectable and borderline resectable pancreatic ductal adenocarcinoma. World J Gastroenterol 2025; 31(32): 109383
URL: https://www.wjgnet.com/1007-9327/full/v31/i32/109383.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i32.109383

Murakami T, Imamura M, Kimura Y, Watanabe K, Shinohara Y, Nakamura T, Low SK, Motoya M, Kawakami Y, Masaki Y, Kubo T, Yoshida M, Yoshida E, Kato T, Kukita K, Kyuno D, Takemasa I. Role of preoperative circulating tumor DNA in predicting occult metastases in resectable and borderline resectable pancreatic ductal adenocarcinoma. World J Gastroenterol 2025; 31(32): 109383 [PMID: 40900777 DOI: 10.3748/wjg.v31.i32.109383]

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