Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis

Table 5 Spearman’s correlations between message RNA expression of estrogen receptors and tumor necrosis factor-alpha, by disease and sex

Spearman’s correlations
		Normal
		Females (n = 18)			Males (n = 18)			Together (n = 36)
		ESR1	ESR2	ESR1	ESR1	ESR2	ESR1	ESR1	ESR2	ESR1
				ESR2			ESR2			ESR2
ESR1	R value		0.01			-0.42			-0.19
	P value		0.9579			0.0861			0.2772
TNF-α	R value	0.05	0.54	-0.38	0.34	-0.11	0.35	0.2	0.18	0.01
	P value	0.8293	0.022a	0.119	0.1708	0.6508	0.16	0.2422	0.2972	0.9501
		HCV/cirrhosis
		Females (n = 15)			Males (n = 17)			Together (n = 32)
		ESR1	ESR2	ESR1	ESR1	ESR2	ESR1	ESR1	ESR2	ESR1
				ESR2			ESR2			ESR2
ESR1	R value		-0.84			0.57			-0.1
	P value		0.0002c			0.0197a			0.6038
TNF-α	R value	-0.3	0.64	-0.57	0.42	0.58	0.07	0.09	0.61	-0.19
	P value	0.2708	0.0116a	0.0286a	0.0934	0.0162a	0.802	0.6165	0.0002c	0.3017
		HCV/HCC
		Females (n = 5)			Males (n = 23)			Together (n = 28)
		ESR1	ESR2	ESR1	ESR1	ESR2	ESR1	ESR1	ESR2	ESR1
				ESR2			ESR2			ESR2
ESR1	R value		-0.1			0.14			0.08
	P value		0.95			0.5814			0.7301
TNF-α	R value	0	0.3	-0.1	-0.11	0.6	-0.56	-0.21	0.45	-0.57
	P value	> 0.99	0.6833	0.95	0.6627	0.0083b	0.0151a	0.3397	0.0293a	0.0049b

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

TNF-α: Tumor necrosis factor-alpha; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus.