Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis

doi:10.3748/wjg.v31.i32.104277

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2025; 31(32): 104277
Published online Aug 28, 2025. doi: 10.3748/wjg.v31.i32.104277

Table 4 Clinical characteristics of hepatitis C virus-positive samples, by sex

Characteristics	Female (n = 20)	Male (n = 35)	P value
Mean AST (U/L)	79.0 ± 44.7	213.8 ± 390.7	0.0186
Mean ALP (U/L)	158.3 ± 112.7	182.1 ± 156.5	0.4255
Mean total bilirubin (mg/dL)	4.8 ± 9.3	7.7 ± 11.6	0.3179
Mean creatinine (mg/dL)	1.4 ± 1.0	1.5 ± 1.0	0.6716

AST: Aspartate aminotransferase; ALP: Alkaline phosphatase.

Citation: Groover S, Addison S, Nicks S, Mwangi M, Brooks A, Kaul A, Kaul R. Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis. World J Gastroenterol 2025; 31(32): 104277
URL: https://www.wjgnet.com/1007-9327/full/v31/i32/104277.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i32.104277