Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery

doi:10.3748/wjg.v31.i31.110582

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Aug 21, 2025 (publication date) through Aug 18, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Aug 21, 2025; 31(31): 110582
Published online Aug 21, 2025. doi: 10.3748/wjg.v31.i31.110582

Table 3 Comparison of postoperative gastrointestinal function among the three groups, mean ± SD/n (%)

	Control (n = 281)	Low-dose (n = 313)	High-dose (n = 285)	Low-dose vs control MD (95%CI)	High-dose vs control MD (95%CI)
Time to first flatus (hour)	76.21 ± 5.32	65.56 ± 5.15^a	64.80 ± 4.90^a	-10.658 (-11.484 to -9.831)	-11.410 (-12.255 to -15.565)
Time to first faces (hour)	96.03 ± 5.14	83.68 ± 5.37^a	82.91 ± 5.47^a	-12.356 (-13.215 to -11.496)	-13.134 (-14.013 to -12.255)
Time to first oral feeding (hour)	85.02 ± 5.40	73.65 ± 4.95^a	72.88 ± 4.80^a	-11.372 (-12.187 to -10.558)	-12.141 (-12.974 to -11.308)
I-FEED score
Normal	197 (70.11)	250 (79.97)^a	221 (77.54)^a
POGI	65 (23.13)	45 (14.48)^a	43 (15.09)^a
POI	19 (6.76)	18 (5.75)	21 (7.37)

^aP < 0.05.

P compared with the control group. MD: Mean difference; CI: Confidence interval; I-FEED score: Intake, feeling nauseated, emesis, physical examination, and duration of symptoms; POGI: Postoperative gastrointestinal intolerance; POI: Postoperative ileus.

Citation: Chen Y, Tang WL, Li CT, Zhao Y, Li B, Liao LM, Lin TH, Zhang LC. Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery. World J Gastroenterol 2025; 31(31): 110582
URL: https://www.wjgnet.com/1007-9327/full/v31/i31/110582.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i31.110582