Dynamic nomogram predicts sepsis risk in patients with acute liver failure: Analysis of intensive care database with external validation

Table 2 Risk factors for sepsis in patients with acute liver failure from the Medical Information Mart for Intensive Care derivation cohort

Parameters	Univariate		Multivariate
	OR (95%CI)	P value	OR (95%CI)	P value
Age (year)	0.984 (0.972-0.996)	0.007	1.016 (1.003-1.028)	0.017
Male	1.066 (0.713-1.622)	0.766
Heart rate	1.016 (1.004-1.027)	0.006
Respiratory rate	1.081 (1.033-1.131)	< 0.001
Na	1.098 (1.048-1.153)	< 0.001
Ca	0.718 (0.575-0.896)	0.003
K	1.317 (1.062-1.633)	0.012
Anion gap	1.085 (1.048-1.123)	< 0.001
Glucose	1.007 (1.002-1.012)	0.006
Granulocytes	1.652 (1.139-2.391)	0.008
WBC	1.076 (1.044-1.112)	< 0.001
Neu	1.081 (1.036-1.128)	< 0.001
RBC	0.765 (0.579-1.012)	0.058
PLT	0.998 (0.996-1.015)	0.085
RDW	1.065 (0.994-1.141)	0.074
HGB	0.877 (0.796-0.967)	0.008
TBil	1.054 (1.015-1.096)	0.007	1.047 (1.008-1.088)	0.017
LDH	1.000 (1.000-1.001)	0.001	1.001 (1.000-1.001)	< 0.001
Cr	1.343 (1.106-1.632)	0.003
Lactate	1.129 (1.032-1.237)	0.009
ALB	0.385 (0.248-0.599)	< 0.001	0.436 (0.274-0.692)	0.003
PH	0.004 (0.003-0.103)	< 0.001
HCO3-	0.910 (0.873-0.948)	< 0.001
Mechanical ventilation	2.019 (1.323-3.082)	< 0.001	1.985 (1.269-3.105)	0.003
Vasopressin	3.687 (1.728-7.869)	< 0.001
Vasoactive	0.749 (0.374-1.517)	0.423

Neu: Neutrophils; RDW: Red cell distribution width; HGB: Hemoglobin; PLT: Platelet; Cr: Creatinine; TBil: Total bilirubin; LDH: Lactate dehydrogenase; ALB: Albumin; OR: Odds ratio.