Clinical efficacy and mechanism of Bletilla striata and Chinese herbal compounds in treatment of peptic ulcer

Table 2 Clinical efficacy of Bletilla striata

Drug combination	Clinical application	Specific effects	Supporting research
Bletilla striata powder combined with esomeprazole or omeprazole	Treatment of peptic ulcer	Inhibits inflammation, promotes ulcer healing, and reduces recurrence	Combination with proton pump inhibitors significantly enhances therapeutic efficacy[19,20]
Combined with rhubarb	Treatment of burns and scalds	Promotes wound contraction and tissue regeneration, and accelerates healing	Synergistic use enhances heat-clearing, detoxification, swelling reduction, and analgesic effects[41]
Ointments and gels containing Bletilla striata	Treatment of skin injuries	Used for chapped skin, acne, and other skin conditions. Demonstrates whitening, anti-inflammatory effects, and serves as an effective wound dressing	Bletilla striata-based topical preparations exhibit significant therapeutic efficacy in dermatological applications[42-44]
Bletilla striata polysaccharide	Antitumor, gastroprotective, and hemostatic effects	Exhibits adjuvant effects against various tumor types, reduces gastric ulcer index, enhances healing rate, and demonstrates significant hemostatic efficacy for pulmonary, gastric, and traumatic bleeding	Bletilla striata polysaccharides show antitumor activity, gastroprotective effects, shortened coagulation time, and enhanced platelet aggregation[45-48]
Other active components	Protection against acute lung injury	Demonstrates significant protective effects against LPS-induced lung injury by reducing neutrophil infiltration and downregulating pro-inflammatory cytokine expression	Bioactive extract EFBS of Bletilla striata exhibits potent anti-inflammatory activity in acute lung injury models[49,50]
Combined with Coptis chinensis and borneol	Other applications	Clinically used in the treatment of herpes zoster, pressure ulcers, and related conditions	Combination therapy enhances anti-inflammatory and analgesic outcomes[51,52]

LPS: Lipopolysaccharide; EFBS: Esophageal foreign body.