Association of triglyceride-glucose index with long-term prognosis in advanced hepatocellular carcinoma patients receiving immunotherapy and targeted therapy

Table 6 Treatment-related adverse events in patients with hepatocellular camrelizumab, n (%)

Variables	Low TyG index (n = 134)	High TyG index (n = 144)	χ2	P value
All grades: Rash	51 (38.06)	62 (43.06)	0.72	0.397
All grades: Nausea	44 (32.84)	53 (36.81)	0.48	0.488
All grades: Fatigue	44 (32.84)	50 (34.72)	0.11	0.740
All grades: Diarrhea	42 (31.34)	47 (32.64)	0.05	0.817
All grades: Hypertension	15 (11.19)	32 (22.22)	6.01	0.014a
All grades: RCCEP	14 (10.45)	16 (11.11)	0.03	0.859
All grades: Hypothyroidism	18 (13.43)	15 (10.42)	0.60	0.437
All grades: Elevated ALT	12 (8.96)	15 (10.42)	0.17	0.681
All grades: Elevated AST	12 (8.96)	17 (11.81)	0.60	0.437
All grades: Thrombocytopenia	10 (7.46)	12 (8.33)	0.07	0.788
All grades: Leukopenia	20 (14.93)	19 (13.19)	0.17	0.678
All grades: Neutropenia	17 (12.69)	15 (10.42)	0.35	0.554
All grades: Proteinuria	8 (5.97)	10 (6.94)	0.11	0.742
All grades: Pneumonitis	8 (5.97)	5 (3.47)	0.97	0.324
All grades: Myocarditis	5 (3.73)	7 (4.86)	0.21	0.643
≥ 3 grades: Rash	22 (16.41)	26 (18.06)	0.13	0.718
≥ 3 grades: Nausea	14 (10.45)	21 (14.58)	1.08	0.299
≥ 3 grades: Fatigue	15 (11.19)	18 (12.50)	0.11	0.737
≥ 3 grades: Diarrhea	10 (7.46)	13 (9.03)	0.22	0.636
≥ 3 grades: Hypertension	5 (3.73)	13 (9.03)	3.22	0.073
≥ 3 grades: RCCEP	2 (1.49)	3 (2.08)	0.01	0.935
≥ 3 grades: Hypothyroidism	5 (3.73)	4 (2.78)	0.01	0.912
≥ 3 grades: Elevated ALT	4 (2.99)	6 (4.17)	0.04	0.837
≥ 3 grades: Elevated AST	3 (2.24)	6 (4.17)	0.32	0.570
≥ 3 grades: Proteinuria	2 (1.49)	2 (1.39)	0.19	0.666
≥ 3 grades: Leukopenia	6 (4.48)	8 (5.56)	0.17	0.681
≥ 3 grades: Neutropenia	5 (3.73)	4 (2.78)	0.01	0.912
≥ 3 grades: Myocarditis	0 (0.00)	2 (1.39)	0.43	0.499
≥ 3 grades: Pneumonitis	0 (0.00)	0 (0.00)	-	-
≥ 3 grades: Thrombocytopenia	0 (0.00)	0 (0.00)	-	-

^aP < 0.05.

TyG: Triglyceride-glucose; RCCEP: Reactive cutaneous capillary endothelial proliferation; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.