Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation

Figure 7 Impact of Xuanshen decoction on oxidative stress and phosphoinositide 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 pathway in slow transit constipation Rats. A: The oxidative stress level (n = 15); B: Western blotting (n = 6). ^bP < 0.01 vs control, ^cP < 0.05 vs model, and ^dP < 0.01 vs model. L-XSD: Low-dose Xuanshen decoction; M-XSD: Medium-dose Xuanshen decoction; H-XSD: High-dose Xuanshen decoction; GSH-PX: Glutathione peroxidase; C-KIT: Tyrosine-protein kinase Kit; SCF: Stem cell factor; HO-1: Heme oxygenase-1; P-PI3K: Phospho-phosphoinositide 3-kinase; PI3K: Phosphoinositide 3-kinase; P-Akt: Phospho-Protein kinase B; Akt:‌ Protein kinase B; Nrf2: Nuclear factor erythroid 2-related factor 2; Nrf2-N: Nuclear-nuclear factor erythroid 2-related factor 2; Nrf2-C: Cytoplasmic nuclear factor erythroid 2-related factor 2.