Mechanism of action of heat-clearing and detoxifying herbs in the treatment of erosive gastritis

Table 2 Efficacy and mechanisms of action of heat-clearing and toxin-resolving Chinese patent medicines in the treatment of erosive gastritis

Drug name	Main ingredients	Efficacy	Action mechanisms	Dosage and duration
Kuidekang Granules[43]	Coptis chinensis, Taraxacum mongolicum, Sophora flavescens, Notoginseng, Astragalus membranaceus, Zhejiang Fritillaria, Bletilla striata, etc.	Clearing heat, harmonizing the stomach, neutralizing acid, and relieving pain[44]	Anti-inflammatory, protect the gastric mucosa, inhibit gastric acid secretion, and regulate gastrointestinal function	10 g per dose, three times daily, for 4-8 weeks
Kangfuxin Liquid[45]	Ethanol extract of dried Periplaneta americana	Promoting blood circulation and nourishing yin to generate tissue	Promote gastric mucosa repair, inhibit inflammatory responses, improve gastric mucosa microcirculation, and regulate immune function	10 mL per dose, three times daily, for 4-6 weeks
Sanjiu Weitai Granules[46]	Evodia lepta, Murraya exotica, Zanthoxylum nitidum, Aucklandia lappa, Scutellaria baicalensis, Poria cocos, Rehmannia glutinosa, Paeonia lactiflora, etc.	Clearing heat, drying dampness, promoting qi, activating blood, soothing the liver, and relieving pain	Inhibit gastric acid secretion, reduce gastric mucosa inflammation, and protect the gastric mucosa barrier	1 bag (15 g) per dose, three times daily, for 4-6 weeks
Weikangling Capsules[47]	Paeonia lactiflora, Bletilla striata, Glycyrrhiza uralensis, Poria cocos, Corydalis yanhusuo, Sepiellae seu Sepiae Endoconcha, Notoginseng radix, Belladonna extract, etc.	Soothing the liver, harmonizing the stomach, dispersing blood stasis, and relieving pain immediately	Inhibit gastric acid secretion, neutralize stomach acid, reduce the irritative effect of stomach acid on the erosive gastric mucosa, anti-inflammatory, and reduce swelling	4 capsules per dose, three times daily, for 4-8 weeks
Lanqin Oral Liquid[48]	Isatis indigotica, Scutellaria baicalensis, Gardenia jasminoides, Phellodendron amurense, Platycarya strobilacea	Clearing heat, detoxification, relieving sore throat, and reducing swelling	Regulate immunity, inhibit inflammatory factors, and reduce gastric mucosa inflammatory response	10 mL per dose, three times daily, for 4-6 weeks
Lianpu Shuangqing Tablets[49]	Berberine hydrochloride, Taraxacum mongolicum extract	Clearing heat, detoxification, drying dampness, and stopping dysentery	Inhibit various gastrointestinal pathogenic bacteria, reduce gastric mucosa inflammation, and promote gastric mucosa repair	4 tablets per dose, three times daily, for 4-6 weeks