Long-term efficacy and short-term outcomes of intersphincteric resection vs abdominoperineal resection in patients with ultra-low rectal cancer

Table 3 Univariate and multivariate Cox regression analyses for overall survival in ultra-low rectal cancer patients after propensity score matching (n = 578)

Variable	Group	n (%)	Univariate analysis HR (95%CI)	P value	Multivariate analysis HR (95%CI)	P value
Surgery	APR	289 (50.0)
	ISR	289 (50.0)	0.546 (0.363-0.820)	0.004	0.554 (0.371-0.828)	0.004
Sex	Female	313 (54.2)
	Male	265 (45.8)	1.108 (0.742-1.656)	0.616
Age (years)	≤ 50	114 (19.7)
	> 50	464 (80.3)	1.068 (0.614-1.859)	0.815
BMI (kg/m2)	≤ 25	466 (80.6)
	> 25	112 (19.4)	1.466 (0.909-2.365)	0.117
CEA (ng/mL)	≤ 5	438 (75.8)
	> 5	140 (24.2)	1.556 (0.990-2.444)	0.055
CA19-9 (U/mL)	≤ 37	527 (91.2)
	> 37	51 (8.8)	1.771 (1.007-3.113)	0.047	2.150 (1.194-3.679)	0.005
pT stage	≤ T3	488 (84.4)
	T4	90 (15.6)	1.109 (0.632-1.947)	0.718
pN stage	N0	386 (66.8)
	N+	192 (33.2)	2.450 (1.067-5.629)	0.035	3.621 (2.426-5.404)	< 0.001
pTNM stage	0-II	386 (66.8)
	III	192 (33.2)	1.292 (0.826-2.022)	0.261
Histopathology	Adenocarcinoma	567 (98.1)
	Mucinous adenocarcinoma	11 (1.9)	1.414 (0.532-3.763)	0.487
nCRT	No	288 (49.8)
	Yes	190 (50.2)	1.687 (1.062-2.679)	0.027
Surgical Procedures	Laparoscopy and Open	564 (97.6)
	Robotic	14 (2.4)	0.765 (0.432-1.355)	0.359
ASA grade	I-II	502 (86.9)
	III	76 (13.1)	1.839 (1.130-2.992)	0.014	1.804 (1.194-2.726)	0.005
Tumour diameter (cm)	≤ 3	214 (37.0)
	> 3	364 (63.0)	0.929 (0.598-1.444)	0.743

ISR: Intersphincteric resection; APR: Abdomen perineal resection; BMI: Body mass index; ASA: American Society of Anesthesiologists; nCRT: Neoadjuvant chemoradiotherapy.