Tetrahydroxylated bile acids prevents malignant progression of Barret esophagus in vitro by inhibiting the interleukin-1β-nuclear factor kappa-B pathway

Figure 5 Effects of deoxycholic acid and tetrahydroxylated bile acids co-exposure on MUC2 gene expression in adult tissue-resident stem cells isolated from Barrett esophagus clinical biopsies. Barrett esophagus clinical biopsies cells treated with deoxycholic acid (DCA) showed decreased level of MUC2 expression by 2.3-fold in comparison to control cells, while tetrahydroxylated bile acids co-treatment significantly restored MUC2 expression in DCA treated cells to over 50 percent of control. Data are presented as mean ± SD (n = 3). ^bP < 0.01. ^cP < 0.001. DCA: Deoxycholic acid; THBA: Tetrahydroxylated bile acids.