Efficacy and safety of triple therapy with vonoprazan for Helicobacter pylori eradication: A multicenter, prospective, randomized controlled trial

doi:10.3748/wjg.v31.i28.109001

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Jul 28, 2025 (publication date) through Aug 9, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Jul 28, 2025; 31(28): 109001
Published online Jul 28, 2025. doi: 10.3748/wjg.v31.i28.109001

Table 4 Noninferiority analysis of Helicobacter pylori eradication rates

	VACa	VACb
Differences from the EBAC group in ITT analysis	15.4	10.8
95%CI for difference	7.3-23.6	2.1-19.4
Noninferior P value	< 0.001^a	0.018^a
Differences from EBAC group in PP analysis	12.5	9.2
95%CI for difference	5.4-19.6	1.6-16.8
Noninferior P value	0.001^a	0.014^a

^aP < 0.025.

EBAC: Esomeprazole/bismuth/amoxicillin/clarithromycin; VACa: 14-day vonoprazan/amoxicillin/clarithromycin; VACb: 10-day vonoprazan/amoxicillin/clarithromycin; CI: Confidence interval; ITT: Intention-to-treat; PP: Per-protocol.

Citation: Han RS, Hao JW, Wang T, Xin Z, Fan GX, Wang GD, Liu MM, Liu CX, Yang QZ, Yang ZW, Lv XY, Zhang C, Bian G, Meng J, Cui ZQ, Yun XJ, Cao JH, Li SH, Fan JF, Ma HG, Gao FY, Mao T, Tian ZB, Song XH, Yu YN. Efficacy and safety of triple therapy with vonoprazan for Helicobacter pylori eradication: A multicenter, prospective, randomized controlled trial. World J Gastroenterol 2025; 31(28): 109001
URL: https://www.wjgnet.com/1007-9327/full/v31/i28/109001.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i28.109001