Efficacy and safety of triple therapy with vonoprazan for Helicobacter pylori eradication: A multicenter, prospective, randomized controlled trial

doi:10.3748/wjg.v31.i28.109001

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Jul 28, 2025 (publication date) through Aug 12, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Jul 28, 2025; 31(28): 109001
Published online Jul 28, 2025. doi: 10.3748/wjg.v31.i28.109001

Table 2 Difference in eradication rates of each therapy group

	EBAC	VACa	VACb	P value	χ²
ITT (%)	72.6	88.0	83.3	0.001	14.409
95%CI	66.0-79.2	83.2-92.8	77.8-88.9
n	127/175	154/175	145/174
PP (%)	81.4	93.9	90.6	0.001	13.341
95%CI	75.3-87.5	90.2-97.6	86.1-95.1
n	127/156	154/164	145/160

EBAC: Esomeprazole/bismuth/amoxicillin/clarithromycin; VACa: 14-day vonoprazan/amoxicillin/clarithromycin; VACb: 10-day vonoprazan/amoxicillin/clarithromycin; CI: Confidence interval; ITT: Intention-to-treat; PP: Per-protocol.

Citation: Han RS, Hao JW, Wang T, Xin Z, Fan GX, Wang GD, Liu MM, Liu CX, Yang QZ, Yang ZW, Lv XY, Zhang C, Bian G, Meng J, Cui ZQ, Yun XJ, Cao JH, Li SH, Fan JF, Ma HG, Gao FY, Mao T, Tian ZB, Song XH, Yu YN. Efficacy and safety of triple therapy with vonoprazan for Helicobacter pylori eradication: A multicenter, prospective, randomized controlled trial. World J Gastroenterol 2025; 31(28): 109001
URL: https://www.wjgnet.com/1007-9327/full/v31/i28/109001.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i28.109001