Construction of a community-based primary screening and hospital-based confirmatory screening pathway in pediatric nonalcoholic fatty liver disease

Table 4 Diagnostic performance of serial tests of the BIU and ATS indices in predicting significant fibrosis

Classification					Sensitivity	Specificity	Accuracy	PPV	NPV
Both BIU and ATS at 90%, sensitivity			LR (ATS)		1.00	0.04	0.58	0.57	1.00
			+	-
	LR (BIU)	+	70	11
		-	19	2
Both BIU and ATS at 90%, specificity			LR (ATS)		0.28	0.98	0.59	0.94	0.52
			+	-
	LR (BIU)	+	17	19
		-	16	50
Both BIU and ATS at 90%, sensitivity			RF (ATS)		0.95	0.31	0.67	0.64	0.82
			+	-
	LR (BIU)	+	42	39
		-	4	17
Both BIU and ATS at 90%, specificity			RF (ATS)		0.58	0.98	0.76	0.97	0.65
			+	-
	LR (BIU)	+	34	2
		-	32	34
Both BIU and ATS at 90%, sensitivity			RF (ATS)
			+	-
	RF (BIU)	+	41	11
		-	5	45	0.95	0.93	0.94	0.95	0.93
Both BIU and ATS at 90%, specificity			RF (ATS)
			+	-
	RF (BIU)	+	58	5
		-	8	31	0.96	0.93	0.95	0.95	0.94

The BIU index is a logistic regression model developed in this study that includes three parameters: Body mass index, insulin, and uric acid. The ATS index is a logistic regression model developed in this study that includes six parameters: Alkaline phosphatase, total bile acid, aspartate aminotransferase, cholinesterase, high-density lipoprotein cholesterol, and fibrinogen. PPV: Positive predictive value; NPV: Negative predictive value.