Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease

Figure 9 Correlation matrix of peripheral neutrophil extracellular trap-associated markers and liver damage markers. A: Thioacetamide model; B: Choline-deficient L-amino acid-defined diet-induced model; C: Cafeteria diet model. Aspartate aminotransferase activity in plasma, alanine aminotransferase activity in plasma, extracellular DNA concentrations in plasma, myeloperoxidase concentrations in plasma, neutrophil elastase concentrations in plasma, score of nonalcoholic steatohepatitis, fibrosis score, neutrophil infiltration into the liver, liver myeloperoxidase concentration, and liver neutrophil elastase concentration. Data are presented Pearson’s r; ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. TAA: Thioacetamide; CAF: Cafeteria; CDAA: Choline-deficient L-amino acid-defined; ecDNA: Extracellular DNA; MPO: Myeloperoxidase; NE: Neutrophil elastase; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; NASH: Nonalcoholic steatohepatitis.