Tenofovir amibufenamide in chronic hepatitis B: Lipid changes and 144-week safety with tenofovir disoproxil fumarate-to-tenofovir amibufenamide switch

doi:10.3748/wjg.v31.i26.109285

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 14, 2025; 31(26): 109285
Published online Jul 14, 2025. doi: 10.3748/wjg.v31.i26.109285

Table 4 Comparison of laboratory finding at 96 weeks in tenofovir disoproxil fumarate/tenofovir amibufenamide groups, mean ± SE

96 weeks	TDF	TMF	P value
WBC	6.87 ± 0.63	6.53 ± 0.28	0.578
Hb	147.50 ± 5.80	149.21 ± 2.78	0.769
PLT	239.14 ± 11.38	213.10 ± 11.67	0.214
ALT	20.62 ± 3.63	23.48 ± 2.31	0.531
AST	22.75 ± 1.15	23.22 ± 1.21	0.830
Cr	77.49 ± 5.63	74.05 ± 2.12	0.485
CLCR	90.04 ± 6.85	100.63 ± 3.44	0.152
PHOS	1.23 ± 0.27	0.88 ± 0.02	0.026
GLU	4.77 ± 0.14	5.65 ± 0.42	0.236
TG	2.42 ± 1.32	1.29 ± 0.13	0.163
CHOL	3.97 ± 0.19	4.64 ± 0.14	0.011
HDL	1.14 ± 0.10	1.37 ± 0.07	0.077
LDL	2.23 ± 0.17	2.95 ± 0.13	0.005
FIB-4	1.12 ± 0.39	1.28 ± 0.24	0.739
CAP	185.17 ± 6.02	202.80 ± 6.26	0.105
miR3	2.35 ± 0.69	2.41 ± 0.42	0.937
RNA	1.29 ± 0.68	0.53 ± 0.23	0.186
DNA	0.29 ± 0.29	0.27 ± 0.16	0.936
HBsAg	2.92 ± 0.13	2.94 ± 0.10	0.874
HBeAg	-0.03 ± 0.32	-0.15 ± 0.18	0.724

TMF: Tenofovir amibufenamide; TDF: Tenofovir disoproxil fumarate; WBC: White blood cells; Hb: Hemoglobin; PLT: Platelet; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; Cr: Creatinine; CLCR: Creatinine clearance; PHOS: Phosphorus; GLU: Glucose; TG: Triglycerides; CHOL: Cholesterol; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; FIB-4: Fibrosis-4; CAP: C-reactive protein; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; miR3: Hepatitis B virus-microRNA-3.

Citation: Zeng ZH, Liu JQ, Zhang M, Qiu CL, Xu ZY. Tenofovir amibufenamide in chronic hepatitis B: Lipid changes and 144-week safety with tenofovir disoproxil fumarate-to-tenofovir amibufenamide switch. World J Gastroenterol 2025; 31(26): 109285
URL: https://www.wjgnet.com/1007-9327/full/v31/i26/109285.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i26.109285