Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer

doi:10.3748/wjg.v31.i26.108662

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Jul 14, 2025 (publication date) through Jul 28, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2025; 31(26): 108662
Published online Jul 14, 2025. doi: 10.3748/wjg.v31.i26.108662

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Figure 3 Histone deacetylases 10 promote tumor proliferation and migration. A: Knockdown of histone deacetylases 10 (HDAC10) expression in SW480 and HCT116 cells at mRNA and protein levels; B: Cell counting kit-8 assay showed HDAC10 depletion inhibited cell proliferation; C: Colony formation analysis indicated HDAC10 knockdown suppressed colony formation; D: Wound-healing assay showed HDAC10 depletion inhibited cell migration. Compared with the siControl group, ^aP < 0.001. Data were represented as mean ± SD of biological triplicates. HDAC10: Histone deacetylases 10.

Citation: Nie HH, Yang XY, Zhou JK, Gao GL, Ding L, Hong YT, Yu YL, Qiu PS, Zeng ZY, Lai J, Zheng T, Wang HZ, Zhao Q, Wang F. Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer. World J Gastroenterol 2025; 31(26): 108662
URL: https://www.wjgnet.com/1007-9327/full/v31/i26/108662.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i26.108662