Ulcerative colitis: Timeline to a cure

Figure 4 Evidence-based pathogenesis of ulcerative colitis. A: Hydrogen peroxide (H₂O₂) diffuses from colonic epithelial cells into the extracellular space and lamina propria; B: The neutrophilic chemotactic effect of H₂O₂ attracts neutrophils into the colonic epithelium; C: H₂O₂ disintegration of tight junctional proteins facilitates bacterial invasion into the sub-epithelial tissues; D: The ensuing mucosal inflammation leads to ulcerative colitis.