Evaluating luminal and post-operative Crohn’s disease activity on magnetic resonance enterography: A review of radiological disease activity scores

Table 6 Operational characteristics of magnetic resonance enterography disease activity scores in luminal Crohn’s disease[14,18-21,26,30,37,38,43,47,48,51-53,56,57,60,80]

MRE disease activity score	MaRIA	Simplified MaRIA	Nancy score	London score	CDMI	Clermont score	MEGS	PICMI	MREI
Diagnostic accuracy
Active disease (segmental)	≥ 7	≥ 1	> 2	≥ 4.1	≥ 3	> 8.4	≥ 6	11-551	≥ 1
Sensitivity (%)	87	90	58	81	87	54	88	85	96
Specificity (%)	87	81	84	70	70	81	75	81	66
AUROC	0.93[18]	0.91[19]	0.77[30]	0.76[43]	0.83[43]	0.68[60]	0.81[26]	0.92[19]	0.96[20]
Moderate disease (segmental)								56-1201
Sensitivity (%)								89
Specificity (%)								86
AUROC								0.93[19]
Severe disease (segmental)	≥ 11	≥ 2				> 12.5		> 1201
Sensitivity (%)	92	85				90		89
Specificity (%)	92	92				80		86
AUROC	0.96[18]	0.94[19]				0.86[60]		0.93[19]
Endoscopy index correlation
SES-CD (r)	0.68-0.78[38,47]	0.94 (ileal); 0.82 (colonic)[56]	0.56[30]	0.80[38]		0.44-0.68[38,60]	0.70[26]	0.63[19]
CDEIS (r)	0.51-0.82[18,21,37,48]	0.72-0.83[19,48]	0.63[57]	0.51[48]	0.56-0.59[37,48]	0.48[60]
Intra-rater agreement
ICC coefficient	0.89[20]		0.96[57]	0.87[20]	0.89[20]			0.81[19]
Inter-rater agreement
ICC coefficient	0.70-0.88[20,51-53]	0.85-0.96[19,51,53,56]	0.85-0.91[53,57]	0.67-0.72[20,52]	0.70-0.78[20,37,52]	0.71-0.76[51,52]	0.84[14]	0.65-0.84[19,37]	0.92[20]
Responsiveness to change
Guyatt’s responsiveness index	1.20[80]	1.13[19]	1.18[57]					1.4[19]
Standardised effect size	0.98[48]	1.17[48]		0.85[48]	0.95[48]
Computation time
Minutes (median)	12.35[51]	4.50[51]				14.30[51]		2.05[19]

¹Total score.

MRE: Magnetic resonance enterography; MaRIA: Magnetic resonance index of activity; CDMI: Crohn’s disease magnetic resonance imaging index; MEGS: Magnetic resonance enterography global score; PICMI: Paediatric inflammatory Crohn’s magnetic resonance enterography index; MREI: Magnetic resonance enterography index; CDEIS: Crohn’s disease endoscopic index of severity; SES-CD: Simple endoscopic score for Crohn’s disease; AUROC: Area under receiver operating characteristic curve; ICC: Intraclass correlation coefficient. Clermont score was not included because comparable parameters were not reported.