Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment

Figure 6 Single-cell RNA analysis in normal and tumor groups. A: Tumor group shows higher mitochondrial features and metabolic activity; B: Mitochondrial gene proportion vs mRNA count correlation; C: Gene loadings on first principal component (PC1) and PC2; D: Significance of PCs in variation capture; E: Eigenvalues of PCs explaining data structure; F: Gene expression separation (normal vs tumor); G: Normal/tumor clusters on PC1-6; H: Key colon cancer-associated genes; I: MarkerGenes expression across cell types; J: Cell classification and spatial distribution; K: Cell type quantity changes in tumors; L: t-distributed Stochastic Neighbor Embedding (t-SNE) cluster distribution; M: 21 color-coded cell clusters; N: Major identified cell types; O: Leucine-rich repeat-containing 19 expression in specific cell types.