Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment

Figure 2 Leucine-rich repeat-containing 19 expression in colorectal cancer tissues and cell lines. A: Leucine-rich repeat-containing 19 (LRRC19) expression is significantly lower in cancer tissues than in normal tissues (^aP < 0.01); B: Validation in an independent clinical cohort (n = 150, ^bP < 0.05); C and D: Immunohistochemical results showing reduced staining in cancer tissues (^bP < 0.05); E: Decreased LRRC19 expression in metastatic colorectal cancer cell lines compared to SW480 (^bP < 0.05), with stable α-tubulin expression.