Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome

Figure 5 Serum metabolomic characteristics of three groups. A: Principal component analysis score plot; B: Orthogonal partial least squares-discriminant analysis (OPLS-DA) for primary biliary cholangitis (PBC) and overlap syndrome (OS); C: OPLS-DA for autoimmune hepatitis (AIH) and OS; D: Assessment of predictive performance and stability of (B); E: Assessment of predictive performance and stability of (D); F: Volcano plot for PBC and OS; G: Volcano plot for AIH and OS; H: Sample clustering heatmap for PBC, AIH, and OS. PBC: Primary biliary cholangitis; AIH: Autoimmune hepatitis; OS: Overlap syndrome; PC: Principal component; VIP: Variable importance in projection.