Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome

doi:10.3748/wjg.v31.i25.106371

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2025; 31(25): 106371
Published online Jul 7, 2025. doi: 10.3748/wjg.v31.i25.106371

Table 4 Significantly altered metabolites in overlap syndrome compared to autoimmune hepatitis

Name	FC	P value	VIP
All-Trans-13,14-dihydroretinol	0.155118	0.002634	2.637447
Alpha-farnesene	0.544136	0.001544	2.616726
PC (14:1e/18:0)	2.137244	0.003936	2.522067
(+/-)-CP 47,497-C7-hydroxy metabolite	0.473641	0.01921	2.325252
PC (16:1e/22:1)	1.939505	0.00826	2.30595
Methyl nicotinate	0.063976	0.045424	2.14672
Octadec-9-ynoic acid	0.502862	0.011726	1.993845
Homo-gamma-linolenic acid (C20:3)	0.49057	0.027711	1.964745
PC (16:1e/22:0)	0.585272	0.012906	1.906264
PC (16:0e/16:0)	1.635313	0.029478	1.902553
Linolelaidic acid (C18:2N6T)	0.649017	0.029729	1.902188
Homoarginine	0.481561	0.016852	1.82961
Mupirocin	0.563021	0.046233	1.817926
Phenylglyoxylic acid	0.286324	0.03155	1.786545
Tetranor-12(S)-HETE	0.433141	0.004515	1.741955
N-Methyldioctylamine	1.530444	0.024254	1.708007
Jasmonic acid	0.545306	0.024253	1.438671
(2S)-2-(2-hydroxypropan-2-yl)-2H,3H,7H-furo[3,2-g]chromen-7-one	0.647968	0.021451	1.313058

FC: Fold change; VIP: Variable importance in projection; PC: Phosphatidylcholine.

Citation: Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371
URL: https://www.wjgnet.com/1007-9327/full/v31/i25/106371.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i25.106371