Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome

Table 3 Significantly altered metabolites in overlap syndrome compared to primary biliary cholangitis

Name	FC	P value	VIP
4-(anilinomethylidene)-3-methyl-4,5-dihydroisoxazol-5-one	1.552696	0.000721	2.639853
2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid	0.370792	0.003842	1.818916
Ergosterol peroxide	3.118903	0.004243	2.925869
Cholest-4-en-3-one	0.40443	0.004499	1.984777
Propionylcarnitine	1.925051	0.004683	2.61661
Fludrocortisone acetate	0.248968	0.005297	1.854885
N-Methyldioctylamine	1.585333	0.005887	2.162885
Proscillaridin A	3.2096	0.009332	2.315147
(+/-)-CP 47,497-C7-hydroxy metabolite	0.544798	0.012931	2.197074
PC (16:1e/22:1)	1.747451	0.014132	2.307943
Octadec-9-ynoic acid	0.440369	0.014988	2.076044
PC (16:1e/22:0)	0.48038	0.016027	2.072384
17beta-Trenbolone	0.574612	0.01804	2.224429
SM (d14:0/14:1)	2.716597	0.018685	2.053585
alpha-farnesene	0.647487	0.022544	1.773355
Trigonelline	0.421173	0.023757	1.652406
LPE 18:2	1.567382	0.025836	1.859335
9-HOTrE	0.616145	0.029622	1.97427
Verapamil hydrochloride	0.563206	0.036	1.803812
Cer-NS (d18:1/16:0)	0.549991	0.037082	1.795717
1,3-dimethyluracil	0.471792	0.037551	1.671353
6-(7-methyloctyl)-1H,3H,4H,6H-furo[3,4-c]furan-1-one	1.971003	0.037965	2.152845
(+/-)5(6)-DiHET	0.366881	0.042184	1.46635
Pilocarpine	0.489733	0.043371	1.922503
PC (3:0/16:4)	1.628991	0.044805	1.521527
Testosterone	0.573249	0.046918	1.426691

FC: Fold change; VIP: Variable importance in projection; PC: Phosphatidylcholine; SM: Sphingomyelin; LPE: Lyso-phosphatidylethanolamine; Cer-NS: Ceramide n-acyl-sphingosine.