Rate of abnormal renal function index and related risk factors in patients with chronic hepatitis B

Table 1 Baseline characteristics of patients with chronic hepatitis B in the entire cohort

	TN group (n = 214)	TE group (n = 286)	P value
Patient characteristics
Age (years)	43.19 ± 10.75	43.47 ± 10.71	0.77
Male, %	58.4	73.8	< 0.05
Family history, %	48.6	54.9	0.10
Hypertension, %	5.1	5.6	0.50
Diabetes, %	4.7	3.8	0.41
Fatty liver, %	35.0	24.1	< 0.05
Fibrosis, %	40.7	30.8	< 0.05
Cirrhosis, %	5.6	18.9	< 0.05
HCC, %	0	1.7	0.06
Laboratory measurements
ALT, U/L	52.28 ± 108.40	29.12 ± 23.20	< 0.05
AST, U/L	34.73 ± 15.21	24.73 ± 47.77	< 0.05
Total bilirubin, μmol/L	13.49 ± 7.06	14.65 ± 8.70	0.11
Direct bilirubin, μmol/L	5.2 ± 3.29	5.52 ± 3.41	0.31
Blood urea nitrogen, mmol/L	4.59 ± 1.18	4.85 ± 1.14	< 0.05
eGFR, mL/min	94.41 ± 16.97	94.10 ± 16.05	0.83
Cholesterol, mmol/L	4.62 ± 0.93	4.29 ± 0.91	< 0.05
Triglyceride, mmol/L	1.28 ± 1.05	1.25 ± 0.97	0.77
High-density lipoprotein, mmol/L	1.40 ± 0.36	1.28 ± 0.34	< 0.05
Low-density lipoprotein, mmol/L	2.94 ± 0.86	2.72 ± 0.80	< 0.05
Abnormal β2-MG, %	54.2	57.7	0.25

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; eGFR: Estimated glomerular filtration rate; β2-MG: β2 microglobulin; TE: Treatment-experienced with any nucleos(t)ide; TN: Treatment-naive with any hepatitis B virus antiviral regimen.