Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats

Figure 4 Perisurgical colony stimulating factor 1-Fc treatment increased macrophage and proinflammatory gene expression after liver ischemia-reperfusion. A-L: Whole liver mRNA expression of Adgre1, Cd163, Cd206, Timd4, Mertk, Ccl2, Csf1, Il34, Csf1r, Tgfb1, Il1b and Il6 in the ischemic and oxygenated lobe 48 hours after ischemia-reperfusion; M: Representative immunohistochemistry images of CD163+ cells and necrosis outlined and indicated with ‘N’; N: Percentages of CD163+ cells were quantified, n = 4-6 for all groups and results were analysed with ordinary two-way ANOVA with Tukey’s multiple comparisons for A-L and Mann Whitney test for N. ^aP < 0.05, ^bP < 0.01, ^cP < 0.0001. Data show mean and standard deviation. IL: Ischemic lobe; OL: Oxygenated lobe; CSF: Colony stimulating factor.