Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation

doi:10.3748/wjg.v31.i23.106949

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Jun 21, 2025 (publication date) through Jun 20, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2025; 31(23): 106949
Published online Jun 21, 2025. doi: 10.3748/wjg.v31.i23.106949

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Figure 1 Schematic diagram of the study design. NLRP3: NLR family pyrin domain containing 3; IL: Interleukin; RT-qPCR: Reverse transcription and quantitative real-time PCR; IHC: Immunohistochemistry; IF: Immunofluorescence; ROS: Reactive oxygen species; CEL: Celastrol; PRED: Prednisolone; LPS: Lipopolysaccharide; ATP: Adenosine triphosphate; HE: Hematoxylin-eosin.

Citation: Zhang MX, Wu C, Feng XX, Tian W, Zhao NH, Lu PP, Ding Q, Liu M. Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation. World J Gastroenterol 2025; 31(23): 106949
URL: https://www.wjgnet.com/1007-9327/full/v31/i23/106949.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i23.106949