Evaluating log odds of positive lymph nodes as a prognostic tool in differentiated gastric cancer: A retrospective study

Table 1 Univariate and multivariate Cox regression analyses of overall survival prognostic factors in 2103 gastric cancer patients

Patient characteristics		Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Sex	Female	Reference	-	-	-
	Male	1.200 (0.998-1.444)	0.052	-	-
Age	< 60	Reference	-	Reference	-
	≥ 60	1.390 (1.214-1.591)	< 0.001	1.409 (1.198-1.657)	< 0.001
BMI	Normal	Reference	-	Reference	-
	Low	1.406 (1.118-1.768)	0.004	1.018 (0.705-1.470)	0.927
	High	0.810 (0.677-0.971)	0.022	0.843 (0.556-1.279)	0.422
Family history	No	Reference	-	-	-
	Yes	1.034 (0.957-1.118)	0.398	-	-
Smoking history	No	Reference	-	-	-
	Yes	1.104 (0.952-1.279)	0.191	-	-
Drinking history	No	Reference	-	Reference	-
	Yes	1.220 (1.044-1.425)	0.012	1.144 (0.970-1.350)	0.110
Surgery methods	Open	Reference	-	Reference	-
	Laparoscopy	0.531 (0.384-0.739)	< 0.001	0.655 (0.473-0.907)	0.011
Pathological type	NMGC	Reference	-	-	-
	MGC	1.163 (0.857-1.578)	0.322	-	-
Vascular tumor thrombus	No	Reference	-	Reference	-
	Yes	1.435 (1.222-1.684)	< 0.001	1.031 (0.871-1.221)	0.722
Nerve invasion	No	Reference	-	Reference	-
	Yes	1.540 (1.312-1.808)	< 0.001	1.079 (0.912-1.277)	0.374
Differentiation	Moderate	Reference	-	Reference	-
	Poor	1.344 (1.158-1.599)	< 0.001	1.268 (1.086-1.479)	0.003
NPLN	NPLN1	Reference	-	Reference	-
	NPLN2	2.472 (2.122-2.879)	< 0.001	1.466 (1.161-1.851)	0.001
NTLN	NTLN1	Reference	-	Reference	-
	NTLN2	1.200 (1.026-1.404)	0.024	1.073 (0.909-1.267)	0.404
LNR	LNR1	Reference	-	Reference	-
	LNR2	2.573 (2.184-3.032)	< 0.001	1.485 (1.157-1.906)	0.002
LODDS	LODDS1	Reference	-	Reference	-
	LODDS2	2.569 (2.174-3.036)	< 0.001	1.515 (1.185-1.938)	< 0.001
pN	N1 + N2	Reference	-	Reference	-
	N3a + N3b	2.364 (2.0382.742)	< 0.001	1.431 (1.163-1.760)	< 0.001
pTNM	I	Reference	-	Reference	-
	II	2.747 (0.984-7.669)	0.054	2.159 (0.770-6.053)	0.143
	III	8.922 (3.339-23.842)	< 0.001	4.238 (1.558-11.527)	0.005
Recurrence or metastasis	No	Reference	-	Reference	-
	Yes	2.202 (1.800-2.694)	< 0.001	1.792 (1.458-2.201)	< 0.001
CA19-9	Low	Reference	-	Reference	-
	High	1.819 (1.558-2.123)	< 0.001	1.480 (1.213-1.804)	< 0.001
CA125	Low	Reference	-	Reference	-
	High	1.607 (1.239-2.084)	< 0.001	1.718 (1.399-2.109)	< 0.001
AFP	Low	Reference	-	Reference	-
	High	1.536 (1.177-2.004)	0.002	1.289 (1.015-1.638)	0.038
CA242	Low	Reference	-	Reference	-
	High	1.788 (1.515-2.110)	< 0.001	1.123 (0.908-1.390)	< 0.284
CA72-4	Low	Reference	-	Reference	-
	High	1.415 (1.195-1.674)	< 0.001	1.400 (1.209-1.622)	< 0.001
CEA	Low	Reference	-	Reference	-
	High	1.327 (1.179-1.482)	< 0.001	1.430 (1.238-1.653)	< 0.001

CI: Confidence interval; HR: Hazard ratio; BMI: Body mass index; MGC: Mucinous gastric adenocarcinoma; NMGC: Non-mucinous gastric adenocarcinoma; pTNM: Pathological tumor-node-metastasis; NPLN: Number of positive lymph nodes; NTLN: Number of total lymph nodes; LNR: Lymph node ratio; LODDS: Log odds of positive lymph nodes; pN: American Joint Committee on Cancer pathologic N stage; CA: Carbohydrate antigen; AFP: Alpha-fetoprotein; CEA: Carcinoembryonic antigen.