Recent advances and challenges in colorectal cancer: From molecular research to treatment

Figure 3 Key features of the four consensus molecular subtypes. Created with MedPeer (medpeer.cn). Copyright permission has been obtained in the Supplementary material. CRC: Colorectal cancer; CMS: Consensus molecular subtypes; CIN-H: High-level chromosome instability; CIMP-H: CpG island methylator phenotype-high; MSI-H: High microsatellite instability; SCNA: Somatic copy number alteration; EMT: Epithelial-mesenchymal transition; TGF-β: Transforming growth factor beta; MAPK: Mitogen-activated protein kinase; STAT: Signal transducer and activator of transcription; EGFR: Epidermal growth factor receptor; JAK: Janus kinase.