Retrospective Cohort Study
Copyright ©The Author(s) 2025.
World J Gastroenterol. Jun 7, 2025; 31(21): 106939
Published online Jun 7, 2025. doi: 10.3748/wjg.v31.i21.106939
Table 3 Univariate and multivariate Cox analysis of the effect of prognostic factors in the original cohort, n (%)
Dependent: Survival (PFS/30, status)
All patients (n = 131)
HR (univariable)
HR (multivariable)
GenderMale76 (58.0)--
Female55 (42.0)0.87 (0.60-1.26, P = 0.458)-
Age> 6066 (50.4)--
≤ 6065 (49.6)0.73 (0.50-1.07, P = 0.110)-
ECOG0-1116 (88.5)--
215 (11.5)1.34 (0.73-2.47, P = 0.340)-
Number of metastatic organs155 (42.0)--
≥ 276 (58.0)1.96 (1.32-2.90, P < 0.001)1.90 (1.27-2.84, P = 0.002)
Primary tumor locationRight colon32 (24.4)--
Left colon and rectum99 (75.6)0.92 (0.61-1.40, P = 0.697)-
Liver metastasisNo46 (35.1)--
Yes85 (64.9)1.57 (1.04-2.36, P = 0.032)1.28 (0.84-1.96, P = 0.254)
Lung metastasisNo70 (53.4)--
Yes61 (46.6)1.23 (0.85-1.78, P = 0.274)-
RAS mutation typeUnknown25 (19.1)--
Wild type20 (15.3)0.97 (0.51-1.85, P = 0.930)-
Mutation86 (65.6)1.37 (0.84-2.24, P = 0.202)-
GroupControl group105 (80.2)--
Experimental group26 (19.8)0.51 (0.31-0.82, P = 0.006)0.49 (0.30-0.80, P = 0.004)