Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis

Figure 2 Results of the IMMUNOME™ protein array analysis. A: Heatmap illustrating the top 50 autoantigens with the most significant differential reactivity between patients with primary biliary cholangitis and pooled normal controls. Antigen selection was based on penetrance fold change analysis; B: Venn diagram showing the overlap of autoantigens with a penetrance frequency of ≥ 20% among the primary biliary cholangitis, autoimmune hepatitis, and chronic hepatitis B groups; C: Venn diagram displaying shared autoantigens with a penetrance frequency of ≥ 30% across the same three disease cohorts. PBC: Primary biliary cholangitis; AIH: Autoimmune hepatitis; CHB: Chronic hepatitis B.