Chaperonin-containing tailless complex polypeptide 1 subunit 6A negatively regulates autophagy and protects colorectal cancer cells from cisplatin-induced cytotoxicity

Figure 2 Cisplatin decreases the protein level of chaperonin-containing tailless complex polypeptide 1 subunit 6a. A: Quantitative PCR was conducted to detect the transcription level of chaperonin-containing tailless complex polypeptide 1 subunit 6a (CCT6A) in both HT29 and SW480 cells following cisplatin (DDP) treatment for 4 hours; B and C: Following treatment with DDP for the indicated period, the whole protein was extracted and subjected to immunoblot analysis with the indicated antibodies. ^bP < 0.01 vs control (Ctrl).