Evaluation of scoring systems and hematological parameters in the severity stratification of early-phase acute pancreatitis

Table 3 Results of univariate and multivariate logistic regression analysis for predicting severe acute pancreatitis

Variables	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age (> 50 years)	1.271 (0.707-2.288)	0.423
Gender	1.066 (0.569-1.999)	0.841
Etiology of AP	0.780 (0.622-0.979)	0.032a	1.191 (0.850-1.668)	0.309
BMI (≥ 25 kg/m2)	1.180 (0.655-2.125)	0.617
Smoking	0.948 (0.724-1.243)	0.701
Comorbidities
Diabetes mellitus	2.059 (1.120-3.785)	0.020a	1.814 (0.807-4.074)	0.149
Hypertension	0.758 (0.396-1.453)	0.404
Coronary artery disease	2.304 (0.821-6.469)	0.113
Chronic kidney disease	0.916 (0.114-7.386)	0.934
Biliary tract disease	0.837 (0.455-1.540)	0.567
Medical attention from symptom onset (hours)	0.995 (0.981-1.010)	0.506
WCC (× 109/L)	1.095 (1.030-1.163)	0.003a	1.071 (0.994-1.155)	0.072
Platelet (× 109/L)	0.997 (0.993-1.002)	0.237
CRPi (mg/L)	1.006 (1.002-1.010)	0.001a	/	/
CRP48 (mg/L)	1.013 (1.009-1.017)	< 0.001a	1.006 (1.001-1.011)	0.010a
HCT (%)	1.020 (0.964-1.079)	0.499
RDW	1.083 (1.002-1.170)	0.044a	1.000 (0.857-1.167)	0.998
GLU (mmol/L)	1.003 (0.994-1.013)	0.521
BUN (mmol/L)	0.999 (0.982-1.017)	0.943
Ca (mmol/L)	0.004 (0.001-0.021)	< 0.001a	0.091 (0.016-0.512)	0.007a
AST (IU/L)	1.001 (1.000-1.002)	0.121
Creatinine (mg/dL)	1.000 (0.997-1.003)	0.993
LDH	1.003 (1.001-1.005)	< 0.001a	1.001 (0.999-1.004)	0.282
D dimer	1.000 (1.000-1.001)	0.002a	1.000 (1.000-1.000)	0.189
Triglyceride	1.030 (1.004-1.056)	0.022a	1.032 (0.996-1.070)	0.086
NLR	1.036 (1.013-1.059)	0.002a	0.992 (0.961-1.024)	0.625
LMR	1.026 (0.975-1.081)	0.321
PLR	1.001 (1.000-1.003)	0.065
PNIi	1.003 (0.997-1.009)	0.277
PNI48	0.765 (0.711-0.823)	< 0.001a	0.822 (0.749-0.902)	< 0.001a

^aP < 0.05.

OR: Odds ratio; CI: Confidence interval; AP: Acute pancreatitis; BMI: Body mass index; WCC: White cell count; CRPi: C-reactive protein measured at admission; CRP₄₈: C-reactive protein measured within 48 hours; HCT: Hematocrit; RDW: Red cell distribution width; GLU: Glucose; BUN: Blood urea nitrogen; AST: Aspartate aminotransferase; LDH: Lactate dehydrogenase; NLR: Neutrophil-lymphocyte ratio; LMR: Lymphocyte-monocyte ratio; PLR: Platelet-lymphocyte ratio; PNI_i: Prognostic nutritional index measured at admission; PNI₄₈: Prognostic nutritional index measured within 48 hours.