Prognostic scoring system using inflammation- and nutrition-related biomarkers to predict prognosis in stage I-III colorectal cancer patients

Table 3 Univariate and multivariate Cox analyses of baseline characteristics and risk score on overall survival in colorectal cancer patients

Characteristics	Univariate analysis HR (95%CI)	P value	Multivariate analysis HR (95%CI)	P value
Age, years
≤ 60	Reference
> 60	0.98 (0.68-1.41)	0.921
Gender
Male	Reference
Female	1.30 (0.90-1.87)	0.163
BMI, kg/m2
≤ 24	Reference
> 24	1.12 (0.78-1.60)	0.550
Smoking
Yes	Reference
No	1.50 (1.00-2.26)	0.051
Alcohol
Yes	Reference
No	1.20 (0.75-1.92)	0.453
Gross appearance
Bulge	Reference		Reference
Infiltration or ulcer	1.58 (1.03-2.42)	0.037	1.06 (0.67-1.68)	0.812
Histological type
Adenocarcinoma	Reference
Mucinous adenocarcinoma or signet ring cell cancer	1.56 (0.86-2.84)	0.141
T stage
T1-T2	Reference		Reference
T3-T4	4.12 (2.09-8.12)	< 0.001	1.66 (0.80-3.43)	0.175
N stage
N0-N1	Reference		Reference
N2-N3	2.40 (1.61-3.58)	< 0.001	1.61 (1.00-2.59)	0.052
TNM stage
I-II	Reference		Reference
III	2.09 (1.46-2.98)	< 0.001	1.26 (0.82-1.93)	0.285
Differentiated degree
Poor/undifferentiated	Reference		Reference
Well/moderate	2.64 (1.77-3.92)	< 0.001	2.04 (1.33-3.13)	0.001
Nerve invasion
Negative	Reference		Reference
Positive	2.48 (1.69-3.66)	< 0.001	1.66 (1.08-2.55)	0.022
Intravascular tumor emboli
Negative	Reference		Reference
Positive	1.56 (1.03-2.37)	0.036	1.05 (0.67-1.65)	0.837
CEA
Normal	Reference		Reference
High	1.69 (1.19-2.42)	0.004	1.25 (0.85-1.82)	0.255
RS
< 266.24	Reference		Reference
≥ 266.24	6.86 (4.77-9.86)	< 0.001	6.62 (4.56-9.62)	< 0.001

BMI: Body mass index; CEA: Carcinoembryonic antigen; RS: Risk factor; HR: Hazard ratio.